The interplay of chaos between the terrestrial and giant planets

We report on some simple experiments on the nature of chaos in our planetary system. We make the following interesting observations. First, we look at the system of Sun + four Jovian planets as an isolated five-body system interacting only via Newtonian gravity. We find that if we measure the Lyapunov time of this system across thousands of initial conditions all within observational uncertainty, then the value of the Lyapunov time seems relatively smooth across some regions of initial condition space, while in other regions it fluctuates wildly on scales as small as we can reliably measure using numerical methods. This probably indicates a fractal structure of Lyapunov exponents measured across initial condition space. Then, we add the four inner terrestrial planets and several post-Newtonian corrections such as general relativity into the model. In this more realistic Sun + eight-planet system, we find that the above structure of chaos for the outer planets becomes uniformly chaotic for almost all planets and almost all initial conditions, with a Lyapunov time-scale of about 5-20 Myr. This seems to indicate that the addition of the inner planets adds more chaos to the system. Finally, we show that if we instead remove the outer planets and look at the isolated five-body system of the Sun + four terrestrial planets, then the terrestrial planets alone show no evidence of chaos at all, over a large range of initial conditions inside the observational error volume. We thus conclude that the uniformity of chaos in the outer planets comes not from the inner planets themselves, but from the interplay between the outer and inner ones. Interestingly, however, there exist rare and isolated initial conditions for which one individual outer planetary orbit may appear integrable over a 200-Myr time-scale, while all the other planets simultaneously appear chaotic. © 2010 The Authors. Journal compilation © 2010 RAS

Differential Morphology Between Rest-frame Optical and UV Emission from 1.5 < z < 3 Star-forming Galaxies

We present the results of a comparative study of the rest-frame optical and rest-frame ultraviolet morphological properties of 117 star-forming galaxies (SFGs), including BX, BzK, and Lyman break galaxies with B<24.5, and 15 passive galaxies in the region covered by the Wide Field Camera 3 Early Release Science program. Using the internal color dispersion (ICD) diagnostic, we find that the morphological differences between the rest-frame optical and rest-frame UV light distributions in 1.4<z<2.9 SFGs are typically small (ICD~0.02). However, the majority are non-zero (56% at >3 sigma) and larger than we find in passive galaxies at 1.4<z<2, for which the weighted mean ICD is 0.013. The lack of morphological variation between individual rest-frame ultraviolet bandpasses in z~3.2 galaxies argues against large ICDs being caused by non-uniform dust distributions. Furthermore, the absence of a correlation between ICD and galaxy UV-optical color suggests that the non-zero ICDs in SFGs are produced by spatially distinct stellar populations with different ages. The SFGs with the largest ICDs (>~0.05) generally have complex morphologies that are both extended and asymmetric, suggesting that they are mergers-in-progress or very large galaxies in the act of formation. We also find a correlation between half-light radius and internal color dispersion, a fact that is not reflected by the difference in half-light radii between bandpasses. In general, we find that it is better to use diagnostics like the ICD to measure the morphological properties of the difference image than it is to measure the difference in morphological properties between bandpasses.Comment: 11 pages, 9 figures, accepted to Ap

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression.

Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which comprise &lt;1% of the genome. Here we leverage a compendium of 58,648 long noncoding RNAs (lncRNAs) to subtype 947 breast cancer samples. We show that lncRNA-based profiling categorizes breast tumours by their known molecular subtypes in breast cancer. We identify a cohort of breast cancer-associated and oestrogen-regulated lncRNAs, and investigate the role of the top prioritized oestrogen receptor (ER)-regulated lncRNA, DSCAM-AS1. We demonstrate that DSCAM-AS1 mediates tumour progression and tamoxifen resistance and identify hnRNPL as an interacting protein involved in the mechanism of DSCAM-AS1 action. By highlighting the role of DSCAM-AS1 in breast cancer biology and treatment resistance, this study provides insight into the potential clinical implications of lncRNAs in breast cancer

Only two out of five articles by New Zealand researchers are free-to-access: a multiple API study of access, citations, cost of Article Processing Charges (APC), and the potential to increase the proportion of open access

We studied journal articles published by researchers at all eight New Zealand universities in 2017 to determine how many were freely accessible on the web. We wrote software code to harvest data from multiple sources, code that we now share to enable others to reproduce our work on their own sample set. In May 2019, we ran our code to determine which of the 2017 articles were open at that time and by what method; where those articles would have incurred an Article Processing Charge (APC) we calculated the cost if those charges had been paid. Where articles were not freely available we determined whether the policies of publishers in each case would have allowed deposit in a non-commercial repository (Green open access). We also examined citation rates for different types of access. We found that, of our 2017 sample set, about two out of every five articles were freely accessible without payment or subscription (41%). Where research was explicitly said to be funded by New Zealand’s major research funding agencies, the proportion was slightly higher at 45%. Where open articles would have incurred an APC we estimated an average cost per article of USD1,682 (for publications where all articles require an APC, that is, Gold open access) and USD2,558 (where APC payment is optional, Hybrid open access) at a total estimated cost of USD1.45m. Of the paid options, Gold is by far more common for New Zealand researchers (82% Gold, 18% Hybrid). In terms of citations, our analysis aligned with previous studies that suggest a correlation between publications being freely accessible and, on balance, slightly higher rates of citation. This is not seen across all types of open access, however, with Diamond OA achieving the lowest rates. Where articles were not freely accessible we found that a very large majority of them (88% or 3089 publications) could have been legally deposited in an institutional repository. Similarly, only in a very small number of cases had a version deposited in the repository of a New Zealand university made the difference between the publication being freely accessible or not (125 publications). Given that most New Zealand researchers support research being open, there is clearly a large gap between belief and practice in New Zealand’s research ecosystem

Frontier AI Regulation: Managing Emerging Risks to Public Safety

Advanced AI models hold the promise of tremendous benefits for humanity, but society needs to proactively manage the accompanying risks. In this paper, we focus on what we term "frontier AI" models: highly capable foundation models that could possess dangerous capabilities sufficient to pose severe risks to public safety. Frontier AI models pose a distinct regulatory challenge: dangerous capabilities can arise unexpectedly; it is difficult to robustly prevent a deployed model from being misused; and, it is difficult to stop a model's capabilities from proliferating broadly. To address these challenges, at least three building blocks for the regulation of frontier models are needed: (1) standard-setting processes to identify appropriate requirements for frontier AI developers, (2) registration and reporting requirements to provide regulators with visibility into frontier AI development processes, and (3) mechanisms to ensure compliance with safety standards for the development and deployment of frontier AI models. Industry self-regulation is an important first step. However, wider societal discussions and government intervention will be needed to create standards and to ensure compliance with them. We consider several options to this end, including granting enforcement powers to supervisory authorities and licensure regimes for frontier AI models. Finally, we propose an initial set of safety standards. These include conducting pre-deployment risk assessments; external scrutiny of model behavior; using risk assessments to inform deployment decisions; and monitoring and responding to new information about model capabilities and uses post-deployment. We hope this discussion contributes to the broader conversation on how to balance public safety risks and innovation benefits from advances at the frontier of AI development.Comment: Update July 11th: - Added missing footnote back in. - Adjusted author order (mistakenly non-alphabetical among the first 6 authors) and adjusted affiliations (Jess Whittlestone's affiliation was mistagged and Gillian Hadfield had SRI added to her affiliations) Updated September 4th: Various typo

Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination

Targeted chromatin remodelling is essential for many nuclear processes, including the regulation of V(D)J recombination. ATP-dependent nucleosome remodelling complexes are important players in this process whose activity must be tightly regulated. We show here that histone acetylation regulates nucleosome remodelling complex activity to boost RAG cutting during the initiation of V(D)J recombination. RAG cutting requires nucleosome mobilization from recombination signal sequences. Histone acetylation does not stimulate nucleosome mobilization per se by CHRAC, ACF or their catalytic subunit, ISWI. Instead, we find the more open structure of acetylated chromatin regulates the ability of nucleosome remodelling complexes to access their nucleosome templates. We also find that bromodomain/acetylated histone tail interactions can contribute to this targeting at limited concentrations of remodelling complex. We therefore propose that the changes in higher order chromatin structure associated with histone acetylation contribute to the correct targeting of nucleosome remodelling complexes and this is a novel way in which histone acetylation can modulate remodelling complex activity